Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081250 | 0.83 | LMNA (0.51) | LMNATSHRSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL20009005 | 0.83 | LMNA (0.51) | LMNATSHRSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL20012508 | 0.74 | LMNA (0.42) | LMNATSHRSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL14731487 | 0.69 | LMNA (0.70) | LMNATSHRSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL3829548 | 0.66 | TSHR (0.39) | LMNATSHRSMN1; SMN2CYP1A2GAA | |
| SCHEMBL799032 | 0.66 | CYP1A2 (0.43) | LMNATSHRSMN1; SMN2CYP1A2GAA | |
| SCHEMBL4248088 | 0.66 | TSHR (0.39) | LMNATSHRSMN1; SMN2CYP1A2GAA | |
| SCHEMBL9446411 | 0.66 | TSHR (0.39) | LMNATSHRSMN1; SMN2CYP1A2GAA | |
| SCHEMBL357615 | 0.66 | CYP1A2 (0.43) | LMNATSHRSMN1; SMN2CYP1A2GAA | |
| SCHEMBL799196 | 0.66 | CYP1A2 (0.43) | LMNATSHRSMN1; SMN2CYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2016138114-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | WO | disclosed |