Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081195 | 0.83 | LMNA (0.55) | LMNATSHRSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL20009005 | 0.80 | LMNA (0.51) | LMNATSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20012508 | 0.73 | LMNA (0.42) | LMNATSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20012510 | 0.69 | VHL (0.51) | — | |
| SCHEMBL18346708 | 0.69 | SIGMAR1 (0.38) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL21064697 | 0.69 | SIGMAR1 (0.38) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL17831928 | 0.69 | SIGMAR1 (0.38) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL20012722 | 0.69 | PTGDR2 (0.54) | TSHRSMN1; SMN2HPGD | |
| SCHEMBL13808999 | 0.68 | MAPT (0.42) | TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL26112622 | 0.68 | SIGMAR1 (0.37) | TSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016138114-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | WO | disclosed |