Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081195 | 0.83 | LMNA (0.55) | LMNACYP1A2TSHRALDH1A1CYP2C9 | |
| SCHEMBL20012508 | 0.80 | LMNA (0.42) | LMNACYP1A2TSHRALDH1A1CYP2C9 | |
| SCHEMBL18081250 | 0.80 | LMNA (0.51) | LMNACYP1A2TSHRALDH1A1CYP2C9 | |
| SCHEMBL26243687 | 0.70 | PRKCB (0.42) | LMNATSHR | |
| SCHEMBL26205553 | 0.70 | SMN1; SMN2 (0.38) | TSHRCYP2D6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27204244 | 0.69 | SMN1; SMN2 (0.40) | TSHRCYP2D6SMN1; SMN2GAA | |
| SCHEMBL27157659 | 0.69 | SMN1; SMN2 (0.40) | TSHRCYP2D6SMN1; SMN2GAA | |
| SCHEMBL20008992 | 0.69 | SMN1; SMN2 (0.40) | TSHRCYP2D6SMN1; SMN2GAA | |
| SCHEMBL16869402 | 0.69 | SMN1; SMN2 (0.40) | TSHRCYP2D6SMN1; SMN2GAA | |
| SCHEMBL20009022 | 0.69 | SMN1; SMN2 (0.40) | TSHRCYP2D6SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | LMNA 1055/4885CYP1A2 4326/4885TSHR 1817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.