Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pyruvate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyruvate SCHEMBL27978365 | 1.00 | TSHR (0.43) | TSHRTHPOFFAR3LCKFYN | |
| Pyruvate SCHEMBL4306224 | 1.00 | TSHR (0.43) | TSHRTHPOFFAR3LCKFYN | |
| Pyruvate SCHEMBL20481778 | 0.96 | TSHR (0.40) | TSHRTHPOFFAR3LCKFYN | |
| Pyruvate SCHEMBL29080978 | 0.85 | PEPD (0.33) | TSHRTHPOFFAR3LCKFYN | |
| Pyruvate SCHEMBL4422058 | 0.85 | TP53 (0.32) | TSHRTHPOFFAR3LCKFYN | |
| Oxalic Acid SCHEMBL4338347 | 0.85 | FFAR3 (0.54) | TSHRTHPOFFAR3LCKFYN | |
| Butanedione SCHEMBL222007 | 0.84 | TSHR (0.64) | TSHRTHPOFFAR3LCKFYN | |
| Phosphoric Acid SCHEMBL284926 | 0.84 | — | — | |
| Phosphoric Acid SCHEMBL7020663 | 0.84 | FFAR3 (0.64) | TSHRTHPOFFAR3LCKFYN | |
| Phosphoric Acid SCHEMBL699429 | 0.84 | FFAR3 (0.64) | TSHRTHPOFFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 345 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113748773-B | Method for preventing fertility decline of film-covered soil based on straw returning | 辽宁省农业科学院 | 2023-01-31 | — | — | CN | claimed |
| WO-2021028876-A1 | MEMBRANE TRANSPORT PROTEIN AND USES THEREOF | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2021-02-18 | — | — | WO | claimed |
| US-10858404-B2 | Engineering crassulacean acid metabolism (CAM) pathways in plants | BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) | 2020-12-08 | — | — | US | claimed |
| CN-110283882-A | There are the methods of mycoplasma pneumoniae in a kind of quick detection clinical sample | 赛莱克斯(深圳)科技有限公司 | 2019-09-27 | — | — | CN | claimed |
| US-20190093122-A1 | ENGINEERING CRASSULACEAN ACID METABOLISM (CAM) PATHWAYS IN PLANTS | BOARD OF REGENTS OF NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF UNIVERSITY (US) | 2019-03-28 | — | — | US | claimed |
| CN-108778308-A | Method for producing RNA molecule composition | 库瑞瓦格股份公司 | 2018-11-09 | — | — | CN | claimed |
| CN-107988126-A | Recombinant microorganism of genetic modification comprising increase by two kinase activity of pyruvate phosphate and application thereof | 三星电子株式会社 | 2018-05-04 | — | — | CN | claimed |
| WO-2017120548-A1 | ENGINEERING CRASSULACEAN ACID METABOLISM (CAM) PATHWAYS IN PLANTS | BOARD OF REGENTS OF NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF UNIVERSITY OF NEVADA, RENO (US) | 2017-07-13 | — | — | WO | claimed |
| CN-102428186-B | Transgenic plants comprising constructs encoding phosphoenolpyruvate carboxykinase and/or pyruvate ortho phos phate dikinase | BRITISH AMERICAN TOBACCO CO | 2014-12-31 | — | — | CN | claimed |
| CN-103998611-A | Polynucleotides, polypeptides and methods for enhancing photossimilation in plants | SYNGENTA PARTICIPATIONS AG | 2014-08-20 | — | — | CN | claimed |
| CN-101400794-A | Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants | CERES INC (US) | 2009-04-01 | — | — | CN | claimed |
| CN-101163801-A | Polymorphism detection method | ENIGMA DIAGNOSTICS LTD (GB) | 2008-04-16 | — | — | CN | claimed |
| CN-101035908-A | Method for determining the amount of template nucleic acid in a sample | LUMORA LTD (GB) | 2007-09-12 | — | — | CN | claimed |
| CN-1944682-A | Determination of alkali base sequence and reagent | HITACHI LTD (JP) | 2007-04-11 | — | — | CN | claimed |
| CN-1304595-C | Analytical method and kit | SECR DEFENCE (GB) | 2007-03-14 | — | — | CN | claimed |
| CN-1854308-A | Basic groups series testing method | HITACHI LTD (JP) | 2006-11-01 | — | — | CN | claimed |
| CN-1174093-C | Polypeptide with low-temperature resistant pyruvate phosphate dikinase activity, corresponding DNA, recombinant vector and transformed plant cell | 日本烟草产业株式会社 | 2004-11-03 | — | — | CN | claimed |
| CN-1140631-C | Method and apparatus for measuring luminescent sample | ������������ʽ���� | 2004-03-03 | — | — | CN | claimed |
| CN-1338003-A | Method and apparatus for measuring sample by luminescence | KIKKOMAN CORP (JP) | 2002-02-27 | — | — | CN | claimed |
| CN-1135770-A | Polypeptide having low-temperature-resistant pyruvate phosphate dikinase activity, DNA encoding the same, recombinant vector containing the DNA, and transformed plant | JAPAN TOBACCO INC (JP) | 1996-11-13 | — | — | CN | claimed |