Butanedione

Butanedione

SCHEMBL222007

CC(=O)C(C)=O.O=P(O)(O)O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Butanedione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.64
THPO P40225 1/20 0.64
CA2 P00918 2/20 0.46
LMNA P02545 3/20 0.42
CA4 P22748 2/20 0.40
FFAR3 O14843 1/20 0.39
LCK P06239 1/20 0.39
FYN P06241 1/20 0.39
MMP2 P08253 2/20 0.37
MMP8 P22894 2/20 0.37
MMP3 P08254 1/20 0.37
CA1 P00915 3/20 0.36
BLM P54132 2/20 0.36
PMP22 Q01453 2/20 0.36
ALOX15 P16050 1/20 0.36
THRB P10828 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butanedione SCHEMBL9294413 0.96 TSHR (0.58) TSHRTHPOCA2LMNACA4
Phosphoric Acid SCHEMBL28210641 0.86 LMNA (0.60) TSHRTHPOCA2LMNAFFAR3
Phosphoric Acid SCHEMBL27514426 0.86 LMNA (0.60) TSHRTHPOCA2LMNAFFAR3
Phosphoric Acid SCHEMBL285413 0.86
Pyruvate SCHEMBL4306224 0.84 TSHR (0.43) TSHRTHPOCA2LMNACA4
Pyruvate SCHEMBL180812 0.84 TSHR (0.43) TSHRTHPOCA2LMNACA4
Pyruvate SCHEMBL27978365 0.84 TSHR (0.43) TSHRTHPOCA2LMNACA4
Phosphoric Acid SCHEMBL11292968 0.82 LMNA (0.55) TSHRTHPOCA2LMNAFFAR3
Phosphoric Acid SCHEMBL7766361 0.82 FFAR3 (0.64) TSHRTHPOCA2LMNAFFAR3
Phosphoric Acid SCHEMBL7020663 0.82 FFAR3 (0.64) TSHRTHPOCA2LMNAFFAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1393 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240374492-A1 A SUNSCREEN COMPOSITION COMPRISING AVOBENZONE AND A METHOD FOR PHOTOSTABILIZATION ISP INVESTMENTS LLC (US) 2024-11-14 US claimed
CN-117430541-B Compounds and compositions for delivery to cells 深圳湾实验室 2024-04-19 CN claimed
CN-117430541-A Compounds and compositions for delivery to cells 深圳湾实验室 2024-01-23 CN claimed
WO-2023009315-A1 A SUNSCREEN COMPOSITION COMPRISING AVOBENZONE AND A METHOD FOR PHOTOSTABILIZATION ISP INVESTMENTS LLC (US) 2023-02-02 WO claimed
US-20220387290-A1 SUNSCREEN COMPOSITIONS AND METHOD OF USE THEREOF ISP INVESTMENTS LLC (US) 2022-12-08 US claimed
EP-3946642-A1 SUNSCREEN COMPOSITIONS AND METHOD OF USE THEREOF ISP Investments LLC (US) 2022-02-09 EP claimed
CN-107072944-B Liposomal ciprofloxacin formulations with anti-nontuberculous mycobacterial activity 阿拉迪姆公司 2021-11-02 CN claimed
WO-2020168336-A1 SUNSCREEN COMPOSITIONS AND METHOD OF USE THEREOF ISP INVESTMENTS LLC (US) 2020-08-20 WO claimed
WO-2020159121-A1 COMPOSITION FOR STABILIZING VITAMIN C DERIVATIVE BY USING GEL STRUCTURE ㈜아모레퍼시픽 2020-08-06 WO claimed
US-9968555-B2 Liposomal formulations that form drug nanocrystals after freeze-thaw ARADIGM CORPORATION (US) 2018-05-15 US claimed
WO-1998051284-A1 NOVEL ACOUSTICALLY ACTIVE DRUG DELIVERY SYSTEMS IMARX PHARMACEUTICAL CORP. (US) 1998-11-19 WO claimed
EP-0802788-A4 NOVEL THERAPEUTIC DELIVERY SYSTEMS UNGER EVAN C (US) 1998-09-09 EP claimed
EP-0712293-A4 METHODS OF PREPARING GAS AND GASEOUS PRECURSOR-FILLED MICROSPHERES UNGER EVAN C (US) 1998-05-06 EP claimed
WO-1997040679-A1 METHODS FOR DELIVERING COMPOUNDS INTO A CELL IMARX PHARMACEUTICAL CORP. (US) 1997-11-06 WO claimed
EP-0802788-A1 NOVEL THERAPEUTIC DELIVERY SYSTEMS UNGER, Evan C (US) 1997-10-29 EP claimed
US-5585112-A TEMPERATURE-ACTIVATED FLUORINE-CONTAINING GAS; USEFUL IN ULTRASONIC IMAGING AND DRUG DELIVERY SYSTEMS; FDA ORANGE BOOK LISTED PATENT FOR PERFLUTREN IMARX PHARMACEUTICAL CORP. (US) 1996-12-17 US claimed
EP-0712293-A1 METHODS OF PREPARING GAS AND GASEOUS PRECURSOR-FILLED MICROSPHERES UNGER, Evan C (US) 1996-05-22 EP claimed
WO-1994028780-A2 METHODS OF PREPARING GAS AND GASEOUS PRECURSOR-FILLED MICROSPHERES UNGER EVAN C (US) 1994-12-22 WO claimed
WO-1994028874-A1 NOVEL THERAPEUTIC DELIVERY SYSTEMS UNGER EVAN C (US) 1994-12-22 WO claimed
US-4416872-A INTERRUPTING LIFE CYCLE OF THE PARASITE IN LIVER OF HOST THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1983-11-22 US claimed