SCHEMBL1808445

SCHEMBL1808445

NS(=O)(=O)c1cccc2cccc(O)c12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 2/20 0.59
CA2 P00918 7/20 0.55
CA1 P00915 6/20 0.55
CA9 Q16790 5/20 0.55
STAT3 P40763 1/20 0.52
CA12 O43570 3/20 0.51
MAPK1 P28482 1/20 0.48
DUSP5 Q16690 1/20 0.46
CA6 P23280 3/20 0.45
CA4 P22748 2/20 0.45
CA5A P35218 2/20 0.45
CA7 P43166 2/20 0.45
CA5B Q9Y2D0 2/20 0.45
CYP2C9 P11712 1/20 0.45
CA14 Q9ULX7 1/20 0.45
MEN1 O00255 1/20 0.45
ALDH1A1 P00352 1/20 0.45
DNMT1 P26358 1/20 0.45
CACNA1B Q00975 1/20 0.45
APBA1 Q02410 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL465006 0.85 CDK2 (0.53) CDK2CA2CA1CA9CA12
SCHEMBL10879225 0.84 MEN1 (0.48) CDK2CA2CA1CA9STAT3
SCHEMBL10354361 0.83 CDK2 (0.51) CDK2CA2CA1CA9CA12
SCHEMBL10354362 0.82 DUSP5 (0.68) CDK2CA2CA1CA9DUSP5
Water SCHEMBL4073018 0.80 DUSP5 (0.66) CDK2CA2CA1CA9DUSP5
SCHEMBL11164601 0.79 ALDH1A1 (0.44) CDK2DUSP5MEN1ALDH1A1DNMT1
SCHEMBL11327506 0.79 DUSP5 (0.64) CDK2CA2CA1CA9STAT3
SCHEMBL1806912 0.79 DUSP5 (0.48) CDK2CA2CA1CA9CA12
SCHEMBL1808443 0.78 CA2 (0.55) CDK2CA2CA1CA9STAT3
SCHEMBL15172852 0.78 CA2 (0.61) CDK2CA2CA1CA9STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1177967-C Enzymatic method for textile dyeing ŵ����÷�����޹�˾ 2004-12-01 CN claimed
US-6805718-B2 USING AROMATIC AMINE, NAPHTHOL OR AMINONAPHTHALENE AND ENZYME NOVOZYMES A/S (DK) 2004-10-19 US claimed
US-20030226215-A1 Enzymatic method for textile dying NOVOZYMES NORTH AMERICA, INC. (US) 2003-12-11 US claimed
CN-1420954-A Enzymatic method for textile dyeing NOVOZYMES AS (DK) 2003-05-28 CN claimed
EP-1266068-A1 ENZYMATIC METHOD FOR TEXTILE DYEING Novozymes North America, Inc. (US) 2002-12-18 EP claimed
US-20010037532-A1 Enzymatic method for textile dyeing NOVOZYMES A/S (DK) 2001-11-08 US claimed
US-6296672-B1 PEROXIDASE, OXIDOREDUCTASE, LACCASE NOVOZYMES A/S PATENTS (DK) 2001-10-02 US claimed
WO-2001044563-A1 ENZYMATIC METHOD FOR TEXTILE DYEING NOVOZYMES NORTH AMERICA, INC. (US) 2001-06-21 WO claimed
WO-2018154519-A1 MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE AbbVie S.à.r.l. (LU) 2018-08-30 WO disclosed
US-20180244611-A1 Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use ABBVIE S.Á.R.L. (LU) 2018-08-30 US disclosed
US-8404036-B2 Water-soluble near-infrared absorbing coloring matters and aqueous inks containing same NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2013-03-26 US disclosed
US-20110123784-A1 WATER-SOLUBLE NEAR-INFRARED ABSORBING COLORING MATTERS AND AQUEOUS INKS CONTAINING SAME NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2011-05-26 US disclosed
US-6805718-B2 USING AROMATIC AMINE, NAPHTHOL OR AMINONAPHTHALENE AND ENZYME NOVOZYMES A/S (DK) 2004-10-19 US disclosed
US-20030226215-A1 Enzymatic method for textile dying NOVOZYMES NORTH AMERICA, INC. (US) 2003-12-11 US disclosed
US-4334004-A Light-sensitive diazotype material with 2-hydroxy-3-naphthoic acid amides having 6-sulfonic acid amide substitution HOECHST AKTIENGESELLSCHAFT (DE) 1982-06-08 US disclosed
US-4321373-A 2-Hydroxy-3-naphthoic acid amides HOECHST AKTIENGESELLSCHAFT (DE) 1982-03-23 US disclosed
EP-0004574-B1 2-HYDROXY-3-NAPHTHALENE CARBOXAMIDES AND THEIR USE AS COUPLING AGENTS IN DIAZOTYPE MATERIALS HOECHST AKTIENGESELLSCHAFT (DE) 1981-12-30 EP disclosed
US-4273850-A 2,5-DIALKOXY-4-ARYLMERCAPTOBENZENE DIAZONIUM SALTS AND A HYDROXYNAPHTHALENE DISULFONAMIDE COUPLER HOECHST AKTIENGESELLSCHAFT (DE) 1981-06-16 US disclosed
EP-0014982-A2 Two-component diazotype material HOECHST AKTIENGESELLSCHAFT (DE) 1980-09-03 EP disclosed
EP-0004574-A1 2-Hydroxy-3-naphthalene carboxamides and their use as coupling agents in diazotype materials HOECHST AKTIENGESELLSCHAFT (DE) 1979-10-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180244611-A1 Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use CFTR, CLCN2, SCNN1G CDK2 4087/4885CA2 1500/4885CA1 4864/4885
US-20110123784-A1 WATER-SOLUBLE NEAR-INFRARED ABSORBING COLORING MATTERS AND AQUEOUS INKS CONTAINING SAME IK, RB1, COL1A1 CDK2 652/4885CA2 1279/4885CA1 798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.