Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.82 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.45 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3643057 | 0.78 | SOS1 (0.77) | SOS1HTR2AHRH1ALDH1A1 | |
| SCHEMBL9684908 | 0.78 | GRIN2B (0.67) | SOS1GRIN2BSIGMAR1GRIN1 | |
| SCHEMBL31119841 | 0.76 | SOS1 (0.52) | SOS1HTR2AHRH1GNAI3GNAO1 | |
| SCHEMBL6014477 | 0.74 | SOS1 (0.50) | SOS1HTR2AHRH1ALDH1A1GRIN2B | |
| SCHEMBL7317273 | 0.73 | GRIN2B (0.65) | SOS1GRIN2BSIGMAR1GRIN1 | |
| SCHEMBL8682833 | 0.73 | GNAI3 (0.67) | SOS1GNAI3GNAO1GNAI1CXCR4 | |
| SCHEMBL6247785 | 0.73 | GNAI3 (0.73) | SOS1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL20648825 | 0.73 | GNAI3 (0.58) | SOS1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL8851760 | 0.71 | SOS1 (0.58) | SOS1GABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL3639265 | 0.71 | SOS1 (0.67) | SOS1HTR2AHRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060271-A1 | SCREENING FOR INHIBITORS OF P. FALCIPARUM USING LUCIFERASE BASED HIGH THROUGHPUT SCREENING ASSAY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-05-19 | — | — | WO | disclosed |
| US-5883099-A | TREATMENT OF ATHERSCLEROSIS, PANCREATITIS OBESITY OR HYPERGLYCEMIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| US-5789197-A | GENETIC ENGINEERING | E. R. SQUIBB & SONS, INC. (US) | 1998-08-04 | — | — | US | disclosed |
| US-5739135-A | PREVENTING OR TREATING ATHEROSCLEROSIS, PANCREATITIS SECONDARY TO HYPERTRIGLYCERIDEMIA, HYPERGLYCEMIA, OBESITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-14 | — | — | US | disclosed |