Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 17/20 | 0.59 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18086812 | 0.89 | RORC (0.73) | RORCPPARG | |
| SCHEMBL16569248 | 0.87 | RORC (0.79) | RORCPPARG | |
| SCHEMBL18086805 | 0.78 | RORC (0.45) | RORCPPARGTP53MAPTTHRB | |
| SCHEMBL18086809 | 0.75 | RORC (0.56) | RORCPPARG | |
| SCHEMBL16582381 | 0.74 | RORC (1.00) | RORCPPARG | |
| SCHEMBL1774122 | 0.69 | TSHR (0.57) | MAPT | |
| SCHEMBL18064625 | 0.69 | RORC (1.00) | RORCPPARG | |
| SCHEMBL23926376 | 0.67 | KDM4A (0.43) | RORCPPARGTP53MAPTTHRB | |
| SCHEMBL30118903 | 0.67 | KDM4A (0.43) | RORCPPARGTP53MAPTTHRB | |
| SCHEMBL18086806 | 0.67 | HTT (0.41) | TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550771-B2 | Keto-imidazopyridine derivatives as RORc modulators | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-9550771-B2 | Keto-imidazopyridine derivatives as RORc modulators | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20160272631-A1 | KETO-IMIDAZOPYRIDINE DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2016-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272631-A1 | KETO-IMIDAZOPYRIDINE DERIVATIVES AS RORc MODULATORS | RORC, RORA, RORB | RORC 1/4885PPARG 132/4885TP53 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.