Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760277 | 0.84 | MAPT (0.55) | ADRA2AADRA2BADRA2CADRA1ANPC1 | |
| SCHEMBL1660192 | 0.83 | MAPT (0.43) | ADRA2AADRA2BADRA2CADRA1ANPC1 | |
| SCHEMBL12678530 | 0.81 | ATM (0.57) | ADRA2AADRA2BADRA2CADRA1ANPC1 | |
| Hydrochloric Acid SCHEMBL2002633 | 0.81 | MAPT (0.43) | ADRA2AADRA2BADRA2CADRA1ANPC1 | |
| SCHEMBL5761857 | 0.81 | PTGES2 (0.45) | ADRA2AADRA2BADRA2CADRA1AKDM4E | |
| SCHEMBL4303130 | 0.81 | NPC1 (0.43) | ADRA2AADRA2BADRA2CADRA1ANPC1 | |
| SCHEMBL4304097 | 0.80 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| SCHEMBL1377373 | 0.80 | KDM4E (0.48) | MAPTKDM4EALDH1A1HPGD | |
| Acetic Acid SCHEMBL4593833 | 0.80 | KDM4E (0.46) | ADRA2AADRA2BADRA2CADRA1ANPC1 | |
| SCHEMBL8632112 | 0.79 | ADRA2A (0.69) | ADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016148145-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUND | 大正製薬株式会社 | 2016-09-22 | — | — | WO | disclosed |