Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660192 | 0.87 | MAPT (0.43) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| Hydrochloric Acid SCHEMBL2002633 | 0.85 | MAPT (0.43) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| SCHEMBL12678530 | 0.85 | ATM (0.57) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| SCHEMBL955247 | 0.84 | TRPV1 (0.51) | — | |
| Hydrochloric Acid SCHEMBL5673491 | 0.83 | TRPV1 (0.50) | — | |
| SCHEMBL1379619 | 0.82 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL2760277 | 0.81 | MAPT (0.55) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| Hydrochloric Acid SCHEMBL537907 | 0.81 | PNMT (0.50) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL5508431 | 0.81 | ADRA2C (0.50) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL5673172 | 0.80 | KDM4E (0.57) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |