Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806658 | 0.87 | MAPK1 (0.33) | PRKCQALDH1A1L3MBTL1MAPK1MAP2K4 | |
| SCHEMBL1803609 | 0.81 | PRKCQ (0.32) | PRKCQALDH1A1CBFB | |
| SCHEMBL1806119 | 0.81 | ALDH1A1 (0.39) | GCGRALDH1A1MAPK1KDM4ENPSR1 | |
| SCHEMBL1807759 | 0.78 | TDP2 (0.42) | ALDH1A1L3MBTL1KDM4ENPC1HTT | |
| SCHEMBL22912511 | 0.70 | NPC1 (0.40) | ALDH1A1L3MBTL1KDM4ENPC1ALOX12 | |
| SCHEMBL1807572 | 0.69 | CYP1A2 (0.32) | — | |
| SCHEMBL1808962 | 0.68 | TTR (0.37) | GCGRALDH1A1NPSR1 | |
| SCHEMBL1806295 | 0.68 | CA12 (0.35) | ALDH1A1L3MBTL1MAPK1KDM4ENPC1 | |
| SCHEMBL1806943 | 0.67 | TDP2 (0.43) | ALDH1A1L3MBTL1NPC1HTTRAB9A | |
| SCHEMBL1806318 | 0.64 | PDE4D (0.50) | ALDH1A1KDM4ENPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501703-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060035-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |