SCHEMBL18090930

SCHEMBL18090930

COc1ccc2c(c1)c1cc(OC)ccc1n2-c1c(C#N)c(-n2c3ccccc3c3ccccc32)c(C#N)c(-n2c3ccc(OC)cc3c3cc(OC)ccc32)c1-n1c2ccc(OC)cc2c2cc(OC)ccc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.56
MAPT P10636 7/20 0.56
ALDH1A1 P00352 5/20 0.56
MEN1 O00255 4/20 0.56
KMT2A Q03164 4/20 0.56
HPGD P15428 4/20 0.56
HTT P42858 3/20 0.56
L3MBTL1 Q9Y468 3/20 0.56
HSD17B10 Q99714 2/20 0.56
LMNA P02545 3/20 0.50
PABPC1 P11940 1/20 0.50
MAPK1 P28482 1/20 0.50
CASP3 P42574 1/20 0.50
NCOA1 Q15788 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
NCOA3 Q9Y6Q9 1/20 0.50
HTR6 P50406 1/20 0.43
RAB9A P51151 3/20 0.38
HCRTR1 O43613 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25626421 0.96 KDM4E (0.57) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL31484565 0.92 KDM4E (0.56) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL21442886 0.85 L3MBTL1 (0.40) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL16175920 0.82 KDM4E (0.43) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL29682014 0.82 KDM4E (0.43) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL29366189 0.82 KDM4E (0.43) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL29413356 0.82 KDM4E (0.43) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL24510245 0.82 L3MBTL1 (0.51) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL20279000 0.82 MAPT (0.44) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL23263969 0.82 ALDH1A1 (0.41) KDM4EMAPTALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160268516-A1 ORGANIC ELECTROLUMINESCENT ELEMENT, ELECTRONIC DEVICE, LIGHT EMITTING DEVICE, AND LIGHT EMITTING MATERIAL Konica Minolta, Inc. (JP) 2016-09-15 US disclosed