Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.67 |
| ▸ | DRD1 | P21728 | 4/20 | 0.67 |
| ▸ | DRD3 | P35462 | 4/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.67 |
| ▸ | DRD4 | P21917 | 3/20 | 0.67 |
| ▸ | BLM | P54132 | 3/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.67 |
| ▸ | DRD5 | P21918 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | GFER | P55789 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL2723670 | 0.87 | KDM4E (0.84) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| Hydrochloric Acid SCHEMBL5688552 | 0.85 | MAPT (0.69) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| SCHEMBL735617 | 0.83 | MAPT (0.68) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| SCHEMBL30637623 | 0.83 | MAPT (0.68) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| Bromide SCHEMBL8585786 | 0.82 | MAPT (0.66) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| Dopamine SCHEMBL23704750 | 0.82 | KDM4E (1.00) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| Dopamine SCHEMBL29831984 | 0.82 | KDM4E (1.00) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| Dopamine SCHEMBL3954271 | 0.82 | KDM4E (1.00) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| Dopamine SCHEMBL30379446 | 0.82 | KDM4E (1.00) | KDM4EMAPTMAPK1SLC6A2LMNA | |
| Dopamine SCHEMBL29636832 | 0.82 | KDM4E (1.00) | KDM4EMAPTMAPK1SLC6A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102085755-B | Solid ink jet printhead having a polymer layer and processes therefor | XEROX CORP | 2013-12-04 | — | — | CN | disclosed |
| US-8303076-B2 | Solid ink jet printhead having a polymer layer and processes therefor | XEROX CORPORATION (US) | 2012-11-06 | — | — | US | disclosed |
| CN-102085755-A | Solid ink jet printhead having a polymer layer and processes therefor | XEROX CORP | 2011-06-08 | — | — | CN | disclosed |
| US-20110102492-A1 | Solid Ink Jet Printhead Having a Polymer Layer and Processes Therefor | XEROX CORPORATION (US) | 2011-05-05 | — | — | US | disclosed |