Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | DRD5 | P21918 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | GFER | P55789 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL40951 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL28324791 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL29636832 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL27754471 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL28285902 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL23704750 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL29831984 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL40952 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL30379446 | 1.00 | KDM4E (1.00) | KDM4EMAPTLMNAMAPK1TDP1 | |
| Dopamine SCHEMBL29201795 | 0.98 | KDM4E (0.96) | KDM4EMAPTLMNAMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122060312-A | Polyether-based lithium battery packaging material and preparation method thereof | 江苏利宏科技发展有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-116327932-A | Preparation method and application of pH response type bionic gold nano-drug for chemotherapy, thermotherapy and targeted therapy | 河南大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-114702713-B | Preparation method of silver niobate fiber-doped polyvinylidene fluoride composite film | 北京理工大学 | 2022-12-09 | — | — | CN | disclosed |
| CN-114344553-B | Polyglutamic acid gastric acid-resistant hemostatic adhesive | 南京工业大学 | 2022-11-25 | — | — | CN | disclosed |
| CN-110100045-B | Reaction products of catechol compounds with functionalized co-reactive compounds for metal pretreatment applications | 汉高股份有限及两合公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-114702713-A | Preparation method of silver niobate fiber-doped polyvinylidene fluoride composite film | 北京理工大学 | 2022-07-05 | — | — | CN | disclosed |
| CN-112029068-B | Polyurethane compound, preparation method thereof and biological binder | 浙江德普斯医疗科技股份有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-114344553-A | Polyglutamic acid gastric acid-resistant hemostatic adhesive | 南京工业大学 | 2022-04-15 | — | — | CN | disclosed |
| CN-114204028-A | Preparation method of polydopamine-coated sodium-ion battery positive electrode material | 南通金通储能动力新材料有限公司 | 2022-03-18 | — | — | CN | disclosed |
| EP-2830633-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | McMaster University (CA) | 2015-02-04 | — | — | EP | disclosed |
| EP-2680853-A1 | TREATMENT OF CANCER WITH DOPAMINE RECEPTOR ANTAGONISTS | McMaster University (CA) | 2014-01-08 | — | — | EP | disclosed |
| WO-2013143000-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | MCMASTER UNIVERSITY (CA) | 2013-10-03 | — | — | WO | disclosed |
| WO-2012116432-A1 | TREATMENT OF CANCER WITH DOPAMINE RECEPTOR ANTAGONISTS | MCMASTER UNIVERSITY (CA) | 2012-09-07 | — | — | WO | disclosed |
| EP-2023874-A4 | METHODS FOR IDENTIFYING AGENTS AND THEIR USE FOR THE PREVENTION OF RESTENOSIS | BIOSEEK INC (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-2023874-A2 | METHODS FOR IDENTIFYING AGENTS AND THEIR USE FOR THE PREVENTION OF RESTENOSIS | Bioseek, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007143211-A2 | METHODS FOR IDENTIFYING AGENTS AND THEIR USE FOR THE PREVENTION OF RESTENOSIS | BIOSEEK, INC. (US) | 2007-12-13 | — | — | WO | disclosed |