Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 12/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285790 | 0.85 | GABRA5 (0.55) | GABRA5KDM4EGAALMNAKMT2A | |
| SCHEMBL18092051 | 0.85 | GABRA5 (0.53) | GABRA5 | |
| SCHEMBL18092024 | 0.81 | GABRA5 (0.52) | GABRA5KDM4E | |
| SCHEMBL285907 | 0.78 | LMNA (0.46) | GABRA5KDM4EGAALMNAKMT2A | |
| SCHEMBL286089 | 0.76 | KDM4E (0.53) | GABRA5KDM4EGAALMNAKMT2A | |
| SCHEMBL18091981 | 0.74 | GABRA5 (0.44) | GABRA5LMNAALDH1A1 | |
| SCHEMBL18092033 | 0.73 | GABRA5 (0.43) | GABRA5ALDH1A1 | |
| SCHEMBL18092056 | 0.73 | GABRA5 (0.55) | GABRA5 | |
| SCHEMBL18092019 | 0.72 | GABRA5 (0.45) | GABRA5KDM4EGAALMNAKMT2A | |
| SCHEMBL18092026 | 0.71 | GABRA5 (0.57) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |