Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 16/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26000537 | 0.89 | FPR2 (0.75) | FPR2TP53NPC1ABCB11CYP1A2 | |
| SCHEMBL21445254 | 0.86 | FPR2 (0.72) | FPR2TP53NPC1ABCB11CYP1A2 | |
| SCHEMBL26002013 | 0.86 | FPR2 (0.71) | FPR2TP53NPC1ABCB11CYP1A2 | |
| SCHEMBL21445264 | 0.84 | FPR2 (1.00) | FPR2TP53NPC1ABCB11CYP1A2 | |
| SCHEMBL30056638 | 0.84 | FPR2 (1.00) | FPR2TP53NPC1ABCB11CYP1A2 | |
| SCHEMBL30534407 | 0.83 | FPR2 (0.69) | FPR2TP53NPC1ABCB11CYP1A2 | |
| SCHEMBL21445268 | 0.83 | FPR2 (0.69) | FPR2TP53NPC1ABCB11CYP1A2 | |
| SCHEMBL23060018 | 0.82 | FPR2 (0.67) | FPR2TP53NPC1ABCB11CYP1A2 | |
| Hydrochloric Acid SCHEMBL23039379 | 0.82 | FPR2 (0.68) | FPR2TP53ABCB11MAPK1MEN1 | |
| SCHEMBL1809214 | 0.81 | FPR2 (0.73) | FPR2TP53ABCB11CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9820990-B2 | Methods of treating disorders associated with protein aggregation | The University of Pittsburgh—Of the Commonwealth System of Higher Education (US) | 2017-11-21 | — | — | US | claimed |
| US-20160361319-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | US | claimed |
| US-9452171-B2 | Methods of treating disorders associated with protein aggregation | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2016-09-27 | — | — | US | claimed |
| US-20150265626-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2015-09-24 | — | — | US | claimed |
| US-9820990-B2 | Methods of treating disorders associated with protein aggregation | The University of Pittsburgh—Of the Commonwealth System of Higher Education (US) | 2017-11-21 | — | — | US | disclosed |
| US-20160361319-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | US | disclosed |
| US-9072772-B2 | Methods of treating disorders associated with protein aggregation | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140047569-A9 | Methods of Treating Disorders Associated with Protein Aggregation | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-02-13 | — | — | US | disclosed |
| US-20130024953-A1 | Methods of Treating Disorders Associated with Protein Aggregation | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2013-01-24 | — | — | US | disclosed |
| WO-2011056222-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160361319-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION | HTT, ATIC, API5 | FPR2 3801/4885TP53 124/4885NPC1 2163/4885 |
| US-20140047569-A9 | Methods of Treating Disorders Associated with Protein Aggregation | HTT, ATIC, API5 | FPR2 3801/4885TP53 124/4885NPC1 2163/4885 |
| US-20130024953-A1 | Methods of Treating Disorders Associated with Protein Aggregation | HTT, ATIC, API5 | FPR2 3801/4885TP53 124/4885NPC1 2163/4885 |
| US-20150265626-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION | HTT, ATIC, API5 | FPR2 3801/4885TP53 124/4885NPC1 2163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.