Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805377 | 0.85 | ERN1 (0.40) | POLBALDH1A1SMN1; SMN2HTTERN1 | |
| SCHEMBL11972726 | 0.85 | POLB (0.32) | POLBALDH1A1SMN1; SMN2HTTMEN1 | |
| SCHEMBL1806128 | 0.82 | ERN1 (0.35) | POLBALDH1A1SMN1; SMN2HTTERN1 | |
| SCHEMBL1808978 | 0.81 | ALDH1A1 (0.37) | POLBALDH1A1SMN1; SMN2HTTERN1 | |
| SCHEMBL11972479 | 0.79 | POLB (0.37) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1806793 | 0.78 | OPRL1 (0.43) | ERN1 | |
| SCHEMBL1808455 | 0.76 | C5AR1 (0.33) | POLBALDH1A1SMN1; SMN2HTTERN1 | |
| SCHEMBL1807552 | 0.76 | POLB (0.33) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1805884 | 0.75 | ERN1 (0.40) | POLBALDH1A1SMN1; SMN2HTTERN1 | |
| SCHEMBL1804786 | 0.75 | LMNA (0.40) | POLBALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |