Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13703856 | 0.84 | KDM4E (0.47) | KDM4EALOX15TSHRL3MBTL1TDP1 | |
| SCHEMBL12362801 | 0.80 | ESR1 (0.44) | KDM4EALOX15TDP1AVPR1ATP53 | |
| SCHEMBL1562163 | 0.80 | L3MBTL1 (0.43) | KDM4EALOX15TSHRL3MBTL1TDP1 | |
| SCHEMBL3421771 | 0.79 | AVPR1A (0.67) | KDM4EALOX15TSHRAVPR1AALDH1A1 | |
| SCHEMBL19142550 | 0.78 | MAPK9 (0.63) | KDM4EALOX15TSHRL3MBTL1TDP1 | |
| SCHEMBL1563395 | 0.78 | LMNA (0.45) | KDM4EALOX15TSHRL3MBTL1TDP1 | |
| SCHEMBL13231655 | 0.75 | KDM4E (0.57) | KDM4EALOX15TSHRL3MBTL1TDP1 | |
| SCHEMBL12713286 | 0.75 | KDM4E (0.52) | KDM4EALOX15TSHRL3MBTL1TDP1 | |
| SCHEMBL9726823 | 0.75 | ALDH1A1 (0.48) | KDM4EALOX15L3MBTL1AVPR1ATP53 | |
| SCHEMBL13543619 | 0.72 | MAPT (0.58) | KDM4EALOX15TSHRL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342178-B1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | SANOFI SA (FR) | 2016-09-28 | — | — | EP | disclosed |