Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 11/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.44 |
| ▸ | TGM2 | P21980 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17661281 | 0.90 | SIRT2 (0.50) | SIRT2SIRT1SIRT3TGM2 | |
| SCHEMBL19017843 | 0.89 | SIRT2 (0.46) | SIRT2SIRT1SIRT3TGM2 | |
| SCHEMBL16847608 | 0.87 | MAPT (0.49) | SIRT2SIRT1SIRT3SIRT5TGM2 | |
| SCHEMBL19017845 | 0.87 | MAPT (0.49) | SIRT2SIRT1SIRT3SIRT5TGM2 | |
| SCHEMBL18100019 | 0.82 | SIRT2 (0.51) | SIRT2SIRT1SIRT3TGM2 | |
| SCHEMBL5550454 | 0.80 | KMT2A (0.46) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL5550449 | 0.80 | KMT2A (0.46) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL12285414 | 0.80 | PSMB8 (0.47) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL31123880 | 0.79 | SIRT5 (0.40) | SIRT2SIRT1SIRT3SIRT5TGM2 | |
| SCHEMBL29768879 | 0.79 | NPC1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160279261-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279261-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | DNPEP, LNPEP, BCR | SIRT2 3885/4885SIRT1 3409/4885SIRT3 4270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.