Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18106971 | 0.91 | MAPT (0.42) | MAPTBAZ2BCFTR | |
| SCHEMBL18106974 | 0.88 | EP300 (0.43) | KITBAZ2BCFTR | |
| SCHEMBL406798 | 0.87 | MAPT (0.45) | MAPTBUB1KITBAZ2BBTK | |
| SCHEMBL18106970 | 0.84 | MAPT (0.42) | MAPTPDGFRB | |
| SCHEMBL409364 | 0.77 | MAPT (0.55) | MAPTBAZ2BCFTR | |
| SCHEMBL407463 | 0.74 | MKNK1 (0.55) | MAPTBAZ2BCFTR | |
| SCHEMBL407207 | 0.71 | MAPT (0.49) | MAPTKITCFTR | |
| SCHEMBL18106968 | 0.65 | MAPT (0.47) | MAPTMAPK14BAZ2B | |
| SCHEMBL404753 | 0.64 | BAZ2B (0.48) | MAPTBAZ2BCFTR | |
| SCHEMBL18106972 | 0.63 | MAPT (0.43) | MAPTKITBAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-B1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |