Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18106971 | 0.92 | MAPT (0.42) | EP300CREBBPMKNK1LIMK2CFTR | |
| SCHEMBL18106969 | 0.88 | PRKAA2 (0.35) | CFTRBAZ2BKIT | |
| SCHEMBL18106970 | 0.87 | MAPT (0.42) | MKNK1KDRTP53 | |
| SCHEMBL407463 | 0.86 | MKNK1 (0.55) | EP300CREBBPMKNK1EGFRCFTR | |
| SCHEMBL18106977 | 0.78 | LIMK2 (0.43) | EP300CREBBPEGFRLIMK2BAZ2B | |
| SCHEMBL409364 | 0.78 | MAPT (0.55) | EP300CREBBPMKNK1CFTRBAZ2B | |
| SCHEMBL406798 | 0.74 | MAPT (0.45) | MKNK1CFTRBAZ2BKIT | |
| SCHEMBL407207 | 0.73 | MAPT (0.49) | MKNK1CFTRKIT | |
| SCHEMBL10139880 | 0.71 | MEN1 (0.56) | EP300CREBBPLIMK2BAZ2BCYP1A2 | |
| SCHEMBL18106979 | 0.70 | TRPV1 (0.42) | LIMK2CFTRBAZ2BCYP1A2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-B1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |