Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 6/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18106974 | 0.92 | EP300 (0.43) | CFTRBAZ2BKDRCYP1A2EP300 | |
| SCHEMBL18106969 | 0.91 | PRKAA2 (0.35) | MAPTCFTRBAZ2B | |
| SCHEMBL18106970 | 0.86 | MAPT (0.42) | MAPTDHFRALDH1A1KDRTRPV1 | |
| SCHEMBL409364 | 0.86 | MAPT (0.55) | MAPTCFTRBAZ2BALDH1A1KDR | |
| SCHEMBL407463 | 0.78 | MKNK1 (0.55) | MAPTCFTRBAZ2BKDREP300 | |
| SCHEMBL406798 | 0.77 | MAPT (0.45) | MAPTCFTRBAZ2BALDH1A1ALOX15 | |
| SCHEMBL18106979 | 0.76 | TRPV1 (0.42) | MAPTCFTRBAZ2BKDRTRPV1 | |
| SCHEMBL407207 | 0.72 | MAPT (0.49) | MAPTCFTRDHFRALDH1A1TRPV1 | |
| SCHEMBL18106977 | 0.71 | LIMK2 (0.43) | MAPTBAZ2BALDH1A1ALOX15EP300 | |
| SCHEMBL10139863 | 0.69 | MAPT (0.56) | MAPTCFTRBAZ2BALDH1A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-B1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |