Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968638 | 0.82 | L3MBTL1 (0.50) | L3MBTL1CHRM2KDM4EALDH1A1TSHR | |
| SCHEMBL19960615 | 0.81 | HRH4 (0.52) | L3MBTL1CHRM2KDM4EKMT2AMEN1 | |
| SCHEMBL969811 | 0.80 | HPGD (0.52) | L3MBTL1CHRM2ALDH1A1TSHR | |
| SCHEMBL18114678 | 0.77 | SIGMAR1 (0.55) | L3MBTL1CHRM2KDM4EALDH1A1HRH4 | |
| SCHEMBL6284952 | 0.77 | HPGD (0.50) | L3MBTL1CHRM2KDM4EALDH1A1TSHR | |
| SCHEMBL17546313 | 0.74 | ACHE (0.57) | KDM4EALDH1A1KMT2A | |
| SCHEMBL18123360 | 0.73 | POLB (0.65) | KMT2AMEN1 | |
| SCHEMBL14353580 | 0.72 | CHRM2 (0.41) | L3MBTL1CHRM2KDM4EALDH1A1KMT2A | |
| SCHEMBL28474171 | 0.72 | CHRM2 (0.42) | L3MBTL1CHRM2KDM4EALDH1A1SLC6A7 | |
| SCHEMBL20084000 | 0.71 | HPGD (0.66) | L3MBTL1KDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016157074-A1 | 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-06 | — | — | WO | disclosed |