Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23585198 | 0.83 | EPHX1 (0.53) | ALDH1A1EPHX1USP30EPHX2 | |
| SCHEMBL21324542 | 0.83 | EPHX1 (0.64) | ALDH1A1EPHX1CYP3A4RAB9AUSP30 | |
| SCHEMBL23585194 | 0.83 | EPHX1 (0.64) | ALDH1A1EPHX1CYP3A4RAB9AUSP30 | |
| SCHEMBL23019780 | 0.83 | EPHX1 (0.64) | ALDH1A1EPHX1CYP3A4RAB9AUSP30 | |
| SCHEMBL13772760 | 0.82 | HPGD (0.45) | ALDH1A1EPHX1RAB9AMAPTL3MBTL1 | |
| SCHEMBL23019797 | 0.82 | EPHX1 (0.53) | ALDH1A1EPHX1USP30EPHX2 | |
| SCHEMBL21324685 | 0.82 | EPHX1 (0.53) | ALDH1A1EPHX1USP30EPHX2 | |
| SCHEMBL23019789 | 0.81 | EPHX1 (0.46) | ALDH1A1EPHX1USP30MEN1MAPT | |
| SCHEMBL13696758 | 0.80 | EPHX1 (0.58) | ALDH1A1EPHX1USP30MEN1MAPT | |
| SCHEMBL23585219 | 0.80 | EPHX1 (0.45) | ALDH1A1EPHX1USP30MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016156816-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2016-10-06 | — | — | WO | disclosed |