Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 5/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 6/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18129463 | 0.91 | MAP4K1 (0.58) | MAP4K1TNIKMAP3K11MAP3K9ABL1 | |
| SCHEMBL18129778 | 0.89 | GSK3B (0.48) | MAP4K1BTKPLCG1GSK3BTNIK | |
| SCHEMBL18129739 | 0.89 | MAP4K1 (0.47) | MAP4K1BTKPLCG1TNIKMAP3K11 | |
| SCHEMBL18129629 | 0.86 | PLK4 (0.55) | BTKGSK3BTNIKMAP3K11AXL | |
| SCHEMBL18129652 | 0.85 | IKBKE (0.43) | MAP4K1BTKPLCG1GSK3BMAP3K11 | |
| SCHEMBL18129806 | 0.85 | TBK1 (0.45) | MAP4K1BTKGSK3BNTRK1CHEK1 | |
| SCHEMBL18129732 | 0.83 | CAMKK2 (0.46) | BTKPLCG1GSK3BMAP3K11AXL | |
| SCHEMBL18129587 | 0.82 | MAP4K1 (0.56) | MAP4K1BTKGSK3BMAP3K11AXL | |
| SCHEMBL18129713 | 0.82 | MAP4K1 (0.55) | MAP4K1BTKMAP3K11AXLNTRK1 | |
| SCHEMBL18129590 | 0.81 | NTRK1 (0.54) | MAP4K1BTKTNIKMAP3K11AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239873-B2 | 7-azaindole or 4,7-diazaindole derivatives as IKKϵ epsilon and TBK1 inhibitor and pharmaceutical composition comprising same | GREEN CROSS CORPORATION (KR) | 2019-03-26 | — | — | US | disclosed |
| US-20160297815-A1 | 7-AZAINDOLE OR 4,7-DIAZAINDOLE DERIVATIVES AS IKK EPSILON AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GREEN CROSS CORPORATION (KR) | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297815-A1 | 7-AZAINDOLE OR 4,7-DIAZAINDOLE DERIVATIVES AS IKK EPSILON AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | TANK, NFKBIA, TBK1 | MAP4K1 766/4885BTK 100/4885PLCG1 1470/4885 |
| US-10239873-B2 | 7-azaindole or 4,7-diazaindole derivatives as IKKϵ epsilon and TBK1 inhibitor and pharmaceutical composition comprising same | NFKBIA, TANK, TBK1 | MAP4K1 858/4885BTK 114/4885PLCG1 1465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.