Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 18/20 | 0.79 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.79 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814541 | 0.91 | ADAMTS5 (0.78) | ADAMTS5ADAMTS4MEN1HSP90AA1RAB9A | |
| SCHEMBL610254 | 0.90 | ADAMTS5 (0.76) | ADAMTS5ADAMTS4TP53POLBMEN1 | |
| SCHEMBL1814298 | 0.89 | ADAMTS5 (0.76) | ADAMTS5ADAMTS4TP53POLBMEN1 | |
| SCHEMBL1815938 | 0.88 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4TP53POLBMEN1 | |
| SCHEMBL1812851 | 0.88 | ADAMTS5 (0.74) | ADAMTS5ADAMTS4TP53POLBMEN1 | |
| SCHEMBL1813190 | 0.88 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4 | |
| SCHEMBL1813188 | 0.88 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4 | |
| SCHEMBL1813659 | 0.88 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4 | |
| SCHEMBL2153807 | 0.88 | ALOX12 (0.75) | ADAMTS5ADAMTS4TP53POLBMEN1 | |
| SCHEMBL5090799 | 0.87 | ADAMTS5 (0.74) | ADAMTS5ADAMTS4TP53POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947712-B2 | Antiarthritic agents; asthma; chronic obstructive pulminary diosrders; atherosclerosis; vision defects; hepatitis; central nervous system disorders; cardiovascular disorders; wound healing agents; restenosis; cirrhosis; multiple sclerosis; glomerulonephritis; graft versus host disease; antidiabetic agent | WYETH LLC (US) | 2011-05-24 | — | — | US | claimed |
| EP-2056823-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | Wyeth (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008024922-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | WYETH (US) | 2008-02-28 | — | — | WO | claimed |
| US-7947712-B2 | Antiarthritic agents; asthma; chronic obstructive pulminary diosrders; atherosclerosis; vision defects; hepatitis; central nervous system disorders; cardiovascular disorders; wound healing agents; restenosis; cirrhosis; multiple sclerosis; glomerulonephritis; graft versus host disease; antidiabetic agent | WYETH LLC (US) | 2011-05-24 | — | — | US | disclosed |
| EP-2056823-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | Wyeth (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008024922-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | WYETH (US) | 2008-02-28 | — | — | WO | disclosed |