Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 10/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.75 |
| ▸ | ADAMTS5 | Q9UNA0 | 7/20 | 0.75 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24634764 | 0.93 | HSP90AA1 (0.75) | ALOX12KDM4EADAMTS5ADAMTS4NPC1 | |
| SCHEMBL30876624 | 0.93 | HSP90AA1 (0.75) | ALOX12KDM4EADAMTS5ADAMTS4NPC1 | |
| SCHEMBL1814298 | 0.90 | ADAMTS5 (0.76) | ALOX12KDM4EADAMTS5ADAMTS4NPC1 | |
| SCHEMBL2153098 | 0.90 | NPC1 (0.80) | ALOX12KDM4EADAMTS5ADAMTS4NPC1 | |
| SCHEMBL27790135 | 0.90 | HSP90AA1 (0.76) | ALOX12KDM4EADAMTS5ADAMTS4NPC1 | |
| SCHEMBL27790138 | 0.88 | NPC1 (0.80) | ALOX12ADAMTS5ADAMTS4NPC1RAB9A | |
| SCHEMBL1813355 | 0.88 | ADAMTS5 (0.79) | ADAMTS5ADAMTS4RAB9AMEN1KMT2A | |
| SCHEMBL2153206 | 0.87 | ADAMTS5 (0.78) | ALOX12KDM4EADAMTS5ADAMTS4NPC1 | |
| SCHEMBL5090799 | 0.87 | ADAMTS5 (0.74) | ADAMTS5ADAMTS4NPC1RAB9AL3MBTL1 | |
| SCHEMBL2153066 | 0.86 | ALOX12 (0.86) | ALOX12KDM4EADAMTS5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | SIERRA SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | SIERRA SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | Zacharon Pharmaceutical, Inc. (US) | 2012-11-22 | — | — | US | disclosed |
| WO-2011082175-A2 | GLYCOSAMINOGLYCAN INHIBITORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | CSGALNACT1, FUT5, ST3GAL3 | ALOX12 3731/4885KDM4E 4113/4885ADAMTS5 108/4885 |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | TERT, TERF2, RNGTT | ALOX12 3130/4885KDM4E 1300/4885ADAMTS5 2882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.