Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.48 |
| ▸ | TP53BP1 | Q12888 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14882630 | 0.87 | USP30 (0.52) | NFKB1NR2C2NFKB2RELATAB1 | |
| SCHEMBL18135106 | 0.86 | CTSA (0.56) | NPC1MAPTRAB9ASMN1; SMN2PKM | |
| SCHEMBL29960561 | 0.86 | HRH4 (0.52) | NFKB1NR2C2NFKB2RELATAB1 | |
| SCHEMBL29115424 | 0.86 | HRH4 (0.52) | NFKB1NR2C2NFKB2RELATAB1 | |
| Hydrochloric Acid SCHEMBL900436 | 0.85 | HRH4 (0.51) | USP30MAPTHTTHRH4TP53BP1 | |
| SCHEMBL10098376 | 0.81 | KDM4E (0.50) | USP30NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2563476 | 0.81 | USP30 (0.43) | NFKB1NR2C2NFKB2RELATAB1 | |
| SCHEMBL14882601 | 0.81 | USP30 (0.47) | NFKB1NR2C2NFKB2RELATAB1 | |
| SCHEMBL15330360 | 0.80 | USP30 (0.45) | NFKB1NR2C2NFKB2RELATAB1 | |
| Hydrochloric Acid SCHEMBL14876289 | 0.80 | KDM4E (0.49) | USP30NPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160297763-A1 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | F. HOFFMANN-LA ROCHE LTD (CH) | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297763-A1 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | ALAD, CYP27A1, FAH | NFKB1 2016/4885NR2C2 2950/4885NFKB2 2928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.