Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 6/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954544 | 0.88 | USP30 (0.50) | USP30HRH4TP53BP1ACACB | |
| SCHEMBL2562359 | 0.86 | USP30 (0.41) | USP30HRH4TP53BP1 | |
| SCHEMBL2563476 | 0.86 | USP30 (0.43) | USP30HRH4TP53BP1NFKB1NR2C2 | |
| SCHEMBL18135099 | 0.80 | NFKB1 (0.51) | USP30HRH4TP53BP1NFKB1NR2C2 | |
| SCHEMBL2555517 | 0.76 | USP30 (0.41) | USP30TP53BP1NFKB1NR2C2NFKB2 | |
| SCHEMBL29951919 | 0.74 | USP30 (0.48) | USP30TP53BP1ACACB | |
| SCHEMBL4687065 | 0.73 | CHKA (0.52) | — | |
| SCHEMBL29115424 | 0.73 | HRH4 (0.52) | USP30HRH4TP53BP1NFKB1NR2C2 | |
| SCHEMBL29960561 | 0.73 | HRH4 (0.52) | USP30HRH4TP53BP1NFKB1NR2C2 | |
| SCHEMBL18135106 | 0.73 | CTSA (0.56) | TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11225655-B2 | Bi-functional complexes and methods for making and using such complexes | NUEVOLUTION A/S (DK) | 2022-01-18 | — | — | US | disclosed |
| EP-3540059-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | Nuevolution A/S (DK) | 2019-09-18 | — | — | EP | disclosed |
| EP-2558577-B1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION AS (DK) | 2018-12-12 | — | — | EP | disclosed |
| US-20130281324-A1 | BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2013-10-24 | — | — | US | disclosed |