Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.45 |
| ▸ | GSK3B | P49841 | 8/20 | 0.45 |
| ▸ | JAK2 | O60674 | 6/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | NOS1 | P29475 | 3/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666610 | 0.83 | NOS1 (0.57) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL6585051 | 0.75 | ROCK2 (0.58) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL15185515 | 0.74 | CTNNB1 (0.55) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL8220180 | 0.73 | ROCK2 (0.54) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL27885403 | 0.73 | MAPK1 (0.51) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL27995718 | 0.73 | NOS1 (0.55) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL27998026 | 0.73 | MAPK1 (0.56) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL28708392 | 0.73 | GRIN2B (0.50) | ROCK2GSK3BJAK2AURKBNOS1 | |
| SCHEMBL28046317 | 0.73 | ROCK2 (0.46) | ROCK2GSK3BNOS1METAP2CSNK2A1 | |
| SCHEMBL15602242 | 0.72 | GSK3B (0.45) | ROCK2GSK3BJAK2AURKBNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738628-B2 | Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160297801-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297801-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | CTNNB1, CTNNBL1, CTNNA1 | ROCK2 2617/4885GSK3B 19/4885JAK2 3143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.