Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138248 | 0.86 | L3MBTL1 (0.46) | NPC1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL12764246 | 0.83 | NPC1 (0.48) | NPC1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL3454821 | 0.80 | NPC1 (0.68) | NPC1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL3676954 | 0.78 | NPC1 (0.47) | NPC1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL18138241 | 0.77 | NOTUM (0.35) | NPC1RAB9A | |
| SCHEMBL30744910 | 0.76 | NPC1 (0.46) | NPC1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL28515221 | 0.76 | NPC1 (0.50) | NPC1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL1973791 | 0.76 | RAB9A (0.52) | NPC1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL18723270 | 0.76 | L3MBTL1 (0.36) | NPC1SMN1; SMN2L3MBTL1RAB9AKMT2A | |
| SCHEMBL18138235 | 0.74 | ALDH1A1 (0.40) | NPC1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |