Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138305 | 0.90 | FGFR4 (0.36) | FGFR4FGFR1FGFR3EGFRFGFR2 | |
| SCHEMBL18138308 | 0.87 | FGFR4 (0.50) | FGFR4FGFR1FGFR3EGFRFGFR2 | |
| SCHEMBL18138366 | 0.86 | FGFR3 (0.32) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL18138307 | 0.82 | FGFR4 (0.43) | FGFR4FGFR1FGFR3EGFRFGFR2 | |
| SCHEMBL18138306 | 0.80 | FGFR4 (0.44) | FGFR4FGFR1FGFR3EGFRFGFR2 | |
| SCHEMBL18138286 | 0.75 | FGFR3 (0.34) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL18138353 | 0.69 | FGFR4 (0.34) | FGFR4FGFR1FGFR3EGFRFGFR2 | |
| SCHEMBL16659420 | 0.69 | FGFR1 (0.33) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL18131318 | 0.69 | FGFR3 (0.31) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL23889743 | 0.68 | FGFR4 (0.37) | FGFR4FGFR1FGFR3FGFR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |