Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138353 | 0.85 | FGFR4 (0.34) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL18138303 | 0.82 | FGFR4 (0.37) | FGFR4FGFR1KMT2AMAPK1FGFR3 | |
| SCHEMBL30745811 | 0.82 | FGFR4 (0.37) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16659621 | 0.82 | FGFR4 (0.37) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL18138306 | 0.82 | FGFR4 (0.44) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL18138305 | 0.81 | FGFR4 (0.36) | FGFR4FGFR1KMT2AMAPK1FGFR3 | |
| SCHEMBL18138308 | 0.79 | FGFR4 (0.50) | FGFR4FGFR1FGFR3EGFRFGFR2 | |
| SCHEMBL28609741 | 0.78 | FGFR1 (0.33) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16655847 | 0.77 | FGFR4 (0.42) | FGFR4FGFR1KMT2AMAPK1FGFR3 | |
| SCHEMBL19633217 | 0.76 | FGFR4 (0.34) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |