Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152038 | 0.87 | OPRD1 (0.41) | OPRD1OPRM1HTR2ADRD2HTR2C | |
| SCHEMBL18153791 | 0.79 | HTR2A (0.44) | KMT2AOPRD1OPRM1HTR2ADRD2 | |
| SCHEMBL18152170 | 0.78 | MEN1 (0.39) | MEN1KMT2AOPRD1OPRM1HTR2A | |
| SCHEMBL18153773 | 0.78 | MEN1 (0.39) | MEN1KMT2AOPRD1OPRM1HTR2A | |
| SCHEMBL28524517 | 0.76 | HTR2C (0.52) | OPRD1OPRM1HTR2ADRD2HTR2C | |
| SCHEMBL18148508 | 0.76 | OPRD1 (0.45) | MEN1KMT2AOPRD1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18159334 | 0.74 | MAPT (0.41) | MEN1KMT2AOPRD1OPRM1ALDH1A1 | |
| SCHEMBL18153894 | 0.74 | MEN1 (0.38) | MEN1KMT2AOPRD1OPRM1HTR2A | |
| SCHEMBL18152127 | 0.74 | MEN1 (0.38) | MEN1KMT2AOPRD1OPRM1HTR2A | |
| SCHEMBL18153708 | 0.74 | MEN1 (0.38) | MEN1KMT2AOPRD1OPRM1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168598-A1 | 3-SPIROCYCLIC-6-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | claimed |
| WO-2016168598-A1 | 3-SPIROCYCLIC-6-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | disclosed |