Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152038 | 0.92 | OPRD1 (0.41) | HTR2AHTR2CDRD2OPRD1OPRM1 | |
| SCHEMBL18144919 | 0.79 | OPRD1 (0.45) | HTR2AHTR2CDRD2OPRD1HRH3 | |
| Hydrochloric Acid SCHEMBL8567312 | 0.79 | HTR2A (0.56) | HTR2AHTR2CDRD2OPRD1HRH3 | |
| SCHEMBL18152041 | 0.79 | MEN1 (0.39) | HTR2AHTR2CDRD2OPRD1OPRM1 | |
| SCHEMBL18165461 | 0.78 | RXRA (0.43) | HTR2AHTR2CDRD2OPRD1HRH3 | |
| SCHEMBL18152144 | 0.76 | OPRM1 (0.38) | OPRD1OPRM1KCNH2KDM4EHPGD | |
| SCHEMBL28524517 | 0.72 | HTR2C (0.52) | HTR2AHTR2CDRD2OPRD1OPRM1 | |
| SCHEMBL18148508 | 0.70 | OPRD1 (0.45) | OPRD1RXRAKCNH2ALDH1A1KMT2A | |
| SCHEMBL11254881 | 0.70 | HTR2C (0.49) | HTR2AHTR2CDRD2OPRD1HRH3 | |
| SCHEMBL18144845 | 0.69 | HDAC6 (0.55) | HTR2AHTR2CDRD2CYP2D6GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168660-A1 | 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | claimed |
| WO-2016168660-A1 | 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | disclosed |