Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152170 | 0.96 | MEN1 (0.39) | MEN1KMT2AACHEOPRM1OPRD1 | |
| SCHEMBL18153740 | 0.91 | ALOX5 (0.41) | MEN1KMT2AOPRM1OPRD1ADRA2A | |
| SCHEMBL18152111 | 0.86 | HSD17B2 (0.40) | MEN1KMT2AOPRM1OPRD1NPC1 | |
| SCHEMBL18152144 | 0.83 | OPRM1 (0.38) | OPRM1OPRD1ADRA2ANPC1RAB9A | |
| SCHEMBL18153894 | 0.80 | MEN1 (0.38) | MEN1KMT2AACHEOPRM1OPRD1 | |
| SCHEMBL18153708 | 0.80 | MEN1 (0.38) | MEN1KMT2AACHEOPRM1OPRD1 | |
| SCHEMBL18152186 | 0.80 | CYP2D6 (0.38) | MEN1KMT2AACHEOPRM1OPRD1 | |
| SCHEMBL18152041 | 0.78 | MEN1 (0.39) | MEN1KMT2AACHEOPRM1OPRD1 | |
| SCHEMBL18152127 | 0.77 | MEN1 (0.38) | MEN1KMT2AACHEOPRM1OPRD1 | |
| SCHEMBL18152169 | 0.77 | MEN1 (0.38) | MEN1KMT2AACHEOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168660-A1 | 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | disclosed |