Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382703 | 0.89 | SMPD1 (0.59) | LMNAALDH1A1L3MBTL1HPGDSMPD1 | |
| SCHEMBL18165179 | 0.80 | KDM4E (0.54) | ALDH1A1L3MBTL1HPGDSMPD1MAPT | |
| SCHEMBL24721712 | 0.80 | LMNA (0.58) | LMNAALDH1A1L3MBTL1HPGDSMPD1 | |
| SCHEMBL18152365 | 0.80 | SYK (0.49) | LMNAL3MBTL1HPGDMAPTRAB9A | |
| SCHEMBL25686475 | 0.79 | MAPT (0.75) | LMNAALDH1A1L3MBTL1HPGDMAPT | |
| SCHEMBL17488408 | 0.79 | ESR1 (0.47) | LMNAALDH1A1L3MBTL1HPGDSMPD1 | |
| SCHEMBL18152331 | 0.79 | BCL9 (0.49) | LMNAHPGDSMPD1HDAC1HDAC8 | |
| SCHEMBL15068193 | 0.79 | NOTUM (0.50) | LMNAALDH1A1L3MBTL1HPGDMAPT | |
| SCHEMBL6294921 | 0.79 | THRA (0.51) | LMNAALDH1A1L3MBTL1SMPD1MAPT | |
| SCHEMBL14914125 | 0.78 | SMPD1 (0.59) | LMNAALDH1A1L3MBTL1HPGDSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168524-A1 | SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-10-20 | — | — | WO | disclosed |