Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.56 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.56 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | PREP | P48147 | 2/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 2/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14295143 | 0.91 | HTT (0.67) | HTTTPSAB1TPSD1TPSG1GAA | |
| SCHEMBL11266194 | 0.91 | HTT (0.63) | HTTTPSAB1TPSD1TPSG1GAA | |
| SCHEMBL7685914 | 0.88 | GAA (0.67) | HTTTPSAB1TPSD1TPSG1GAA | |
| SCHEMBL11266633 | 0.88 | GAA (0.67) | HTTTPSAB1TPSD1TPSG1GAA | |
| SCHEMBL18165184 | 0.85 | SIGMAR1 (0.64) | HTTTPSAB1TPSD1TPSG1GAA | |
| SCHEMBL17294006 | 0.85 | SIGMAR1 (0.64) | HTTTPSAB1TPSD1TPSG1GAA | |
| SCHEMBL27795955 | 0.84 | PREP (0.56) | HTTGAASIGMAR1PREPLMNA | |
| SCHEMBL14711499 | 0.84 | HTT (0.57) | HTTTPSAB1TPSD1TPSG1GAA | |
| SCHEMBL31697361 | 0.82 | LMNA (0.56) | HTTGAASIGMAR1DPP8DPP7 | |
| SCHEMBL17294010 | 0.81 | SIGMAR1 (0.59) | HTTSIGMAR1PREPDPP8DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168524-A1 | SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-10-20 | — | — | WO | disclosed |