Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.58 |
| ▸ | C5AR1 | P21730 | 6/20 | 0.52 |
| ▸ | BCL9 | O00512 | 4/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20021931 | 0.88 | MGLL (0.60) | MGLLC5AR1BCL9CTNNB1TP53 | |
| SCHEMBL18165102 | 0.82 | MGLL (0.52) | MGLLC5AR1BCL9CTNNB1MAPT | |
| SCHEMBL20025818 | 0.79 | BCL9 (0.48) | MGLLC5AR1BCL9CTNNB1ALDH1A1 | |
| SCHEMBL9126984 | 0.77 | MGLL (0.57) | MGLLC5AR1TP53MAPTPTPN1 | |
| SCHEMBL27815058 | 0.75 | MGLL (0.71) | MGLLTP53MAPTNPC1ALDH1A1 | |
| SCHEMBL18152284 | 0.75 | PTGDR2 (0.49) | BCL9CTNNB1MAPTNPC1ALDH1A1 | |
| SCHEMBL18152329 | 0.74 | BCL9 (0.79) | MGLLBCL9CTNNB1MAPTSMN1; SMN2 | |
| SCHEMBL18152413 | 0.74 | CTNNB1 (0.77) | BCL9CTNNB1 | |
| SCHEMBL21062557 | 0.73 | MGLL (0.52) | MGLLBCL9CTNNB1TP53MAPT | |
| SCHEMBL21062556 | 0.73 | MGLL (0.52) | MGLLBCL9CTNNB1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168524-A1 | SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-10-20 | — | — | WO | disclosed |