Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517500 | 0.86 | ALDH1A1 (0.68) | RAB9AALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL3619479 | 0.84 | ALDH1A1 (0.70) | RAB9AALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL4112742 | 0.83 | ALDH1A1 (0.62) | RAB9AALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL27825360 | 0.82 | ALDH1A1 (0.56) | RAB9AALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL15127704 | 0.82 | RAB9A (0.58) | RAB9AALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL9696775 | 0.82 | CACNA1B (0.67) | RAB9AALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL4121515 | 0.82 | RAB9A (0.63) | RAB9AALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL16753828 | 0.81 | MAPT (0.59) | RAB9AALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL16509081 | 0.80 | CYP1A1 (0.62) | RAB9AALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL8238688 | 0.80 | GSK3B (0.59) | RAB9AALDH1A1KMT2AMEN1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283464-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME (US) | 2019-10-23 | — | — | EP | disclosed |
| US-10081617-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-09-25 | — | — | US | disclosed |
| US-20180079743-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-03-22 | — | — | US | disclosed |
| EP-3283464-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168098-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079743-A1 | FACTOR XIa INHIBITORS | F11, F2, TFPI | RAB9A 1969/4885ALDH1A1 3638/4885HPGD 1530/4885 |
| US-10081617-B2 | Factor XIa inhibitors | F11, F2, TFPI | RAB9A 1969/4885ALDH1A1 3638/4885HPGD 1530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.