Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806134 | 0.89 | SMN1; SMN2 (0.80) | SMN1; SMN2ALDH1A1GAATP53NPSR1 | |
| SCHEMBL1813423 | 0.84 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL20357282 | 0.83 | ALDH1A1 (0.79) | SMN1; SMN2ALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL29636844 | 0.82 | ALDH1A1 (0.77) | SMN1; SMN2ALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL23406402 | 0.82 | ALDH1A1 (0.77) | SMN1; SMN2ALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL1811373 | 0.81 | ALDH1A1 (0.83) | SMN1; SMN2ALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL12653712 | 0.81 | CRHBP (0.71) | SMN1; SMN2ALDH1A1GAATP53NPSR1 | |
| SCHEMBL11526649 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1GAATP53NPSR1 | |
| SCHEMBL12653714 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH1A1GAATP53NPSR1 | |
| SCHEMBL30360590 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH1A1GAATP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011061277-A1 | AMINO ARYL ACETAMIDES AND THEIR USE IN THE TREATMENT OF MALARIA | GLAXO GROUP LIMITED (GB) | 2011-05-26 | — | — | WO | disclosed |
| WO-2011061277-A1 | AMINO ARYL ACETAMIDES AND THEIR USE IN THE TREATMENT OF MALARIA | GLAXO GROUP LIMITED (GB) | 2011-05-26 | — | — | WO | disclosed |