Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18150087 | 0.88 | BRAF (0.53) | NQO1MAPK1LMNATP53MEN1 | |
| SCHEMBL18154540 | 0.85 | ALDH1A1 (0.46) | NQO1MAPK1LMNATP53MEN1 | |
| SCHEMBL18150080 | 0.81 | TP53 (0.49) | NQO1MAPK1LMNATP53MEN1 | |
| SCHEMBL1800595 | 0.80 | CA1 (0.56) | NQO1MAPK1LMNATP53MEN1 | |
| SCHEMBL28996989 | 0.80 | NQO1 (0.58) | NQO1MAPK1LMNATP53MEN1 | |
| SCHEMBL12472605 | 0.78 | MAPT (0.66) | MAPK1LMNATP53MEN1CYP3A4 | |
| SCHEMBL29169913 | 0.76 | KMT2A (0.60) | MAPK1LMNATP53MEN1CYP3A4 | |
| SCHEMBL15527966 | 0.76 | CA1 (0.56) | MAPK1LMNATP53MEN1CYP3A4 | |
| SCHEMBL28143419 | 0.76 | KDM4E (0.56) | NQO1MAPK1LMNATP53MEN1 | |
| SCHEMBL27699860 | 0.74 | NPC1 (0.48) | NQO1MAPK1LMNATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283481-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016166239-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | WO | disclosed |