Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353158 | 1.00 | ALDH1A1 (0.39) | ALDH1A1HTTHPGDL3MBTL1LMNA | |
| SCHEMBL18154686 | 0.84 | AKR1B1 (0.43) | POLBNR3C2GRM4 | |
| SCHEMBL30353170 | 0.84 | AKR1B1 (0.43) | POLBNR3C2GRM4 | |
| SCHEMBL18154788 | 0.84 | KMT2A (0.40) | ALDH1A1HTTL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL30353164 | 0.82 | PIK3C3 (0.42) | ALDH1A1LMNARAB9AMAPTTDP1 | |
| SCHEMBL18154717 | 0.82 | PIK3C3 (0.42) | ALDH1A1LMNARAB9AMAPTTDP1 | |
| SCHEMBL18154795 | 0.81 | NAMPT (0.38) | ALDH1A1HTTHPGDL3MBTL1LMNA | |
| SCHEMBL18154720 | 0.80 | LMNA (0.43) | ALDH1A1HTTHPGDL3MBTL1LMNA | |
| SCHEMBL18154704 | 0.77 | ALDH1A1 (0.34) | ALDH1A1HTTHPGDL3MBTL1LMNA | |
| SCHEMBL18154848 | 0.76 | MEN1 (0.44) | ALDH1A1HTTL3MBTL1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-A1 | PLK4 INHIBITORS | Ludwig Institute for Cancer Research Ltd (CH) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016166604-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2016-10-20 | — | — | WO | disclosed |