Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353164 | 1.00 | PIK3C3 (0.42) | PIK3C3JAK1CYP2C19MAPTTDP1 | |
| SCHEMBL18154795 | 0.85 | NAMPT (0.38) | CYP2C19MAPTLMNATSHRNAMPT | |
| SCHEMBL30353158 | 0.82 | ALDH1A1 (0.39) | MAPTTDP1LMNARAB9AALDH1A1 | |
| SCHEMBL18154809 | 0.82 | ALDH1A1 (0.39) | MAPTTDP1LMNARAB9AALDH1A1 | |
| SCHEMBL18154686 | 0.79 | AKR1B1 (0.43) | CA2KMT2A | |
| SCHEMBL30353170 | 0.79 | AKR1B1 (0.43) | CA2KMT2A | |
| SCHEMBL18154848 | 0.78 | MEN1 (0.44) | MAPTLMNACA2RAB9AKMT2A | |
| SCHEMBL18154728 | 0.77 | PTGS2 (0.36) | MAPTTDP1LMNATSHRCA2 | |
| SCHEMBL18154720 | 0.77 | LMNA (0.43) | CYP2C19MAPTTDP1LMNARAB9A | |
| SCHEMBL18154704 | 0.76 | ALDH1A1 (0.34) | MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-A1 | PLK4 INHIBITORS | Ludwig Institute for Cancer Research Ltd (CH) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016166604-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2016-10-20 | — | — | WO | disclosed |