Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 2/20 | 0.50 |
| ▸ | TOP2A | P11388 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18164074 | 0.93 | MET (0.46) | METTGFB2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18155103 | 0.80 | SYK (0.51) | METTGFB2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18155084 | 0.79 | TGFB2 (0.52) | METTGFB2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14091276 | 0.77 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KDM4EMEN1MAPT | |
| SCHEMBL18155038 | 0.76 | AURKA (0.52) | METTGFB2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18164007 | 0.75 | TGFB2 (0.52) | METTGFB2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14906643 | 0.75 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2KDM4EMEN1MAPT | |
| SCHEMBL18155077 | 0.75 | BRD4 (0.49) | METTGFB2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18163900 | 0.73 | TGFB2 (0.59) | METTGFB2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18155091 | 0.73 | FGFR1 (0.50) | METTGFB2ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | claimed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | disclosed |