Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30358126 | 0.78 | ALDH1A1 (0.67) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL18155343 | 0.78 | ALDH1A1 (0.67) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL12082468 | 0.78 | DRD2 (0.62) | ALDH1A1MAPTLMNASMN1; SMN2ACHE | |
| SCHEMBL13023352 | 0.78 | TUBB4A (0.45) | ALDH1A1MAPTHPGDLMNAHSD17B10 | |
| SCHEMBL13023405 | 0.78 | MEN1 (0.45) | ALDH1A1MAPTHPGDLMNAHSD17B10 | |
| SCHEMBL8342531 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNASMN1; SMN2ACHE | |
| SCHEMBL17191282 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL21015682 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL12385910 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNASMN1; SMN2ACHE | |
| SCHEMBL15759137 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9468632-B2 | Methods and compositions for targeting cancer stem cells | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-10-18 | — | — | US | disclosed |