Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18155246 | 0.91 | HSD17B10 (0.37) | HRH1HTR6HSD17B10KDM4EMEN1 | |
| SCHEMBL13654437 | 0.89 | KDM4E (0.34) | KDM4EDRD1KCNH2GAAMAPT | |
| SCHEMBL18155267 | 0.88 | HRH1 (0.39) | HRH1HTR6HSD17B10KDM4EMEN1 | |
| SCHEMBL1120646 | 0.87 | KDM4E (0.34) | HSD17B10KDM4EMEN1KMT2ACYP1A2 | |
| SCHEMBL13663461 | 0.87 | HTR6 (0.38) | HRH1HTR6HSD17B10KDM4EMEN1 | |
| SCHEMBL18155247 | 0.87 | HRH1 (0.38) | HRH1HTR6HSD17B10KDM4EMEN1 | |
| SCHEMBL18155286 | 0.85 | HTR6 (0.40) | HRH1HTR6HSD17B10KDM4EMEN1 | |
| SCHEMBL18155259 | 0.85 | KDM4E (0.36) | HSD17B10KDM4EMEN1KMT2ACYP1A2 | |
| SCHEMBL18155277 | 0.83 | HSD17B10 (0.33) | HRH1HTR6HSD17B10KDM4EMEN1 | |
| SCHEMBL18155322 | 0.80 | MAPT (0.32) | HRH1HTR6HSD17B10KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469641-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-10-18 | — | — | US | disclosed |