Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109020 | 0.88 | ALOX15 (0.66) | ALOX15RAB9AMAPTSNCATOP1 | |
| SCHEMBL10242035 | 0.86 | MAOA (0.59) | ALOX15RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL11563350 | 0.85 | POLB (0.53) | RAB9AMAPTNPC1HSP90AA1HSP90AB1 | |
| SCHEMBL4686246 | 0.82 | HSP90AA1 (0.53) | RAB9AMAPTNPC1HSP90AA1HSP90AB1 | |
| SCHEMBL7547627 | 0.81 | ALDH1A1 (0.59) | RAB9AMAPTNPC1SMN1; SMN2HSP90AA1 | |
| SCHEMBL19427497 | 0.81 | ALOX15 (0.63) | ALOX15RAB9AMAPTSNCAALDH1A1 | |
| SCHEMBL13804531 | 0.81 | ALDH1A1 (0.55) | ALOX15MAPTSMN1; SMN2POLBSNCA | |
| SCHEMBL12937374 | 0.81 | TOP1 (0.74) | ALOX15RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL13772128 | 0.79 | ALOX15 (0.71) | ALOX15RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL22125519 | 0.78 | SMARCA2 (0.69) | RAB9ANPC1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469605-B2 | Compounds and compositions for use a modulators of tau aggregation and alleviation of tauopathies | PROTAMED, INC. (US) | 2016-10-18 | — | — | US | disclosed |