Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3883024 | 0.87 | TYR (0.46) | ERN1CCNB2CDK1CDK4CCNB1 | |
| SCHEMBL18155194 | 0.86 | MAPK1 (0.41) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL3035265 | 0.80 | MAPT (0.50) | ERN1CCNB2CDK1CDK4CCNB1 | |
| SCHEMBL4567003 | 0.79 | FFAR4 (0.46) | ERN1CCNB2CDK1CDK4CCNB1 | |
| SCHEMBL6262057 | 0.78 | FFAR4 (0.51) | L3MBTL1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL865350 | 0.78 | MAOA (0.58) | ERN1CCNB2CDK1CDK4CCNB1 | |
| SCHEMBL13956364 | 0.78 | ERN1 (0.52) | ERN1CCNB2CDK1CDK4CCNB1 | |
| SCHEMBL20032400 | 0.77 | MRGPRX4 (0.51) | ERN1L3MBTL1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL1311076 | 0.77 | HDAC8 (0.65) | ERN1HDAC8MAPTNPC1RAB9A | |
| SCHEMBL12978551 | 0.77 | LMNA (0.43) | ERN1MAPK1HTTHTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9468632-B2 | Methods and compositions for targeting cancer stem cells | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-10-18 | — | — | US | disclosed |