Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ERN1 | O75460 | 3/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865350 | 0.89 | MAOA (0.58) | HDAC8MAOBPOLBMAPTERN1 | |
| SCHEMBL2573994 | 0.88 | TUBB1 (0.57) | HDAC8ALDH1A1MAOBKDM4EERN1 | |
| SCHEMBL435043 | 0.88 | ALDH1A1 (0.61) | HDAC8ALDH1A1MAOBKDM4EPOLB | |
| SCHEMBL4622268 | 0.87 | HDAC8 (0.68) | HDAC8ALDH1A1MAOBKDM4EPOLB | |
| SCHEMBL4622274 | 0.87 | HDAC8 (0.68) | HDAC8ALDH1A1MAOBKDM4EPOLB | |
| SCHEMBL1963431 | 0.87 | HDAC8 (0.52) | HDAC8ALDH1A1MAOBKDM4EPOLB | |
| SCHEMBL3971633 | 0.87 | HDAC8 (0.54) | HDAC8ALDH1A1MAOBKDM4EPOLB | |
| SCHEMBL21370452 | 0.87 | NPC1 (0.61) | HDAC8ALDH1A1MAOBPOLBMAPT | |
| SCHEMBL3211263 | 0.86 | HDAC8 (0.51) | HDAC8ALDH1A1MAOBKDM4EPOLB | |
| SCHEMBL9077095 | 0.86 | ALDH1A1 (0.58) | HDAC8ALDH1A1HTTTRIM24TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045428-B2 | Substituted heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2015-06-02 | — | — | US | claimed |
| US-8716319-B2 | Substituted heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2014-05-06 | — | — | US | claimed |
| US-20130324525-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2013-12-05 | — | — | US | claimed |
| CN-101691324-B | Method for preparing 3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxy)-1-propanol | UNIV SHANGHAI | 2013-04-03 | — | — | CN | claimed |
| CN-101691324-A | Method for preparing 3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxy)-1-propanol | UNIV SHANGHAI | 2010-04-07 | — | — | CN | claimed |
| CN-111184866-B | Combination treatment of bacterial infections | 香港中文大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-107868091-B | Meddigesin, derivatives thereof and preparation method thereof | 怀特生技新药股份有限公司 | 2020-08-28 | — | — | CN | disclosed |
| CN-111184866-A | Combination therapy for bacterial infections | 香港中文大学 | 2020-05-22 | — | — | CN | disclosed |
| CN-104710438-B | The volution compound and its preparation method and application for promoting iPS cell to generate | 中国科学院上海药物研究所 | 2019-11-29 | — | — | CN | disclosed |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | PHYTOHEALTH CORPORATION (TW) | 2019-08-20 | — | — | US | disclosed |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | PHYTOHEALTH CORPORATION (TW) | 2019-08-20 | — | — | US | disclosed |
| EP-2342194-B1 | OXOAZETIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RES & DEV (FR) | 2018-08-08 | — | — | EP | disclosed |
| EP-0773930-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1997-05-21 | — | — | EP | disclosed |
| US-5559105-A | ANTAGONIST FOR ENDOTHELIN RECEPTORS, HYPOTENSIVE AGENTS, TREATMENT OF KIDNEY FAILURE OR CEREBROVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-24 | — | — | US | disclosed |
| WO-1996003380-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1996-02-08 | — | — | WO | disclosed |
| EP-0650484-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994002474-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-02-03 | — | — | WO | disclosed |
| US-4664929-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |
| US-4633006-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1986-12-30 | — | — | US | disclosed |
| US-4490296-A | Compositions and method | ROUSSEL UCLAF (FR) | 1984-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | SHARPIN, ATP6V1B1, REN | HDAC8 4358/4885ALDH1A1 2007/4885MAOB 1618/4885 |
| US-20130324525-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | NQO1, GPR119, GLP1R | HDAC8 1951/4885ALDH1A1 274/4885MAOB 272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.